3sq3

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[[Image:3sq3.jpg|left|200px]]
 
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==Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H182A Mutant==
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The line below this paragraph, containing "STRUCTURE_3sq3", creates the "Structure Box" on the page.
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<StructureSection load='3sq3' size='340' side='right'caption='[[3sq3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sq3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SQ3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sq3 OCA], [https://pdbe.org/3sq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3sq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sq3 ProSAT]</span></td></tr>
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{{STRUCTURE_3sq3| PDB=3sq3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYDP1_YEAST TYDP1_YEAST] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Cleaves also 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II. Contributes to DNA repair after radiation damage. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).<ref>PMID:10521354</ref> <ref>PMID:16751265</ref>
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===Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H182A Mutant===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22155078 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22155078}}
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gajewski S]]
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==About this Structure==
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[[Category: White SW]]
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[[3sq3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQ3 OCA].
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==Reference==
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<ref group="xtra">PMID:022155078</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Gajewski, S.]]
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[[Category: White, S W.]]
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[[Category: Dna binding]]
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[[Category: Hydrolase]]
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[[Category: Nuclear]]
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[[Category: Phosphodiesterase]]
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Current revision

Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H182A Mutant

PDB ID 3sq3

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