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2l9i

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[[Image:2l9i.jpg|left|200px]]
 
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==NMR structure of thymosin alpha-1==
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The line below this paragraph, containing "STRUCTURE_2l9i", creates the "Structure Box" on the page.
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<StructureSection load='2l9i' size='340' side='right'caption='[[2l9i]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_2l9i| PDB=2l9i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9i OCA], [https://pdbe.org/2l9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9i RCSB], [https://www.ebi.ac.uk/pdbsum/2l9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTMA_HUMAN PTMA_HUMAN] Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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800MHz NMR structure of the 28-residue peptide thymosin alpha-1 in 40% TFE/60% water (v/v) has been determined. Restrained molecular dynamic simulations with an explicit solvent box containing 40% TFE/60% TIP3P water (v/v) were used, in order to get the 3D model of the NMR structure. We found that the peptide adopts a structured conformation having two stable regions: an alpha-helix region from residues 14 to 26 and two double beta-turns in the N-terminal twelve residues which form a distorted helical structure.
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===NMR structure of thymosin alpha-1===
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NMR structure of human thymosin alpha-1.,Elizondo-Riojas MA, Chamow SM, Tuthill CW, Gorenstein DG, Volk DE Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):356-61. Epub 2011 Nov 15. PMID:22115779<ref>PMID:22115779</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22115779}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2l9i" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22115779 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22115779}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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[[2l9i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9I OCA].
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[[Category: Large Structures]]
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[[Category: Elizondo-Riojas MA]]
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==Reference==
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[[Category: Gorenstein DG]]
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<ref group="xtra">PMID:022115779</ref><references group="xtra"/>
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[[Category: Volk DE]]
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[[Category: Elizondo-Riojas, M A.]]
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[[Category: Gorenstein, D G.]]
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[[Category: Volk, D E.]]
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[[Category: Immunopotentiation]]
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[[Category: Lymphocyte membrane binding peptide]]
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[[Category: Peptide binding protein]]
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[[Category: T-cell differentiation]]
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[[Category: Transcription]]
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Current revision

NMR structure of thymosin alpha-1

PDB ID 2l9i

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