3ntp

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[[Image:3ntp.jpg|left|200px]]
 
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==Human Pin1 complexed with reduced amide inhibitor==
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The line below this paragraph, containing "STRUCTURE_3ntp", creates the "Structure Box" on the page.
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<StructureSection load='3ntp' size='340' side='right'caption='[[3ntp]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ntp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.762&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=RZD:(2R)-2-(ACETYLAMINO)-3-[(2S)-2-{[2-(1H-INDOL-3-YL)ETHYL]CARBAMOYL}PYRROLIDIN-1-YL]PROPYL+DIHYDROGEN+PHOSPHATE'>RZD</scene></td></tr>
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{{STRUCTURE_3ntp| PDB=3ntp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ntp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ntp OCA], [https://pdbe.org/3ntp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ntp RCSB], [https://www.ebi.ac.uk/pdbsum/3ntp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ntp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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===Human Pin1 complexed with reduced amide inhibitor===
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==See Also==
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*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21980916 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21980916}}
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==About this Structure==
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[[3ntp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTP OCA].
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==Reference==
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<ref group="xtra">PMID:021980916</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Phosphorylation regulation]]
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[[Category: Prolyl isomerase]]
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Current revision

Human Pin1 complexed with reduced amide inhibitor

PDB ID 3ntp

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OCA

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