3s32

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[[Image:3s32.png|left|200px]]
 
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==Crystal structure of Ash2L N-terminal domain==
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The line below this paragraph, containing "STRUCTURE_3s32", creates the "Structure Box" on the page.
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<StructureSection load='3s32' size='340' side='right'caption='[[3s32]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s32]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3s32| PDB=3s32 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s32 OCA], [https://pdbe.org/3s32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s32 RCSB], [https://www.ebi.ac.uk/pdbsum/3s32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s32 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the beta-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the beta-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.
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===Crystal structure of Ash2L N-terminal domain===
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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.,Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. PMID:21642971<ref>PMID:21642971</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3s32" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21642971 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21642971}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA].
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==Reference==
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<ref group="xtra">PMID:021642971</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Avdic, V.]]
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[[Category: Large Structures]]
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[[Category: Blais, A.]]
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[[Category: Avdic V]]
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[[Category: Brand, M.]]
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[[Category: Blais A]]
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[[Category: Brunzelle, J S.]]
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[[Category: Brand M]]
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[[Category: Chaturvedi, C P.]]
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[[Category: Brunzelle JS]]
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[[Category: Couture, J F.]]
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[[Category: Chaturvedi C-P]]
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[[Category: Lanouette, S.]]
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[[Category: Couture J-F]]
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[[Category: Sarvan, S.]]
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[[Category: Lanouette S]]
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[[Category: Tremblay, V.]]
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[[Category: Sarvan S]]
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[[Category: Zhang, P.]]
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[[Category: Tremblay V]]
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[[Category: C4-zinc finger]]
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[[Category: Zhang P]]
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[[Category: Chromatin]]
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[[Category: Helix-wing-helix]]
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[[Category: Histone]]
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[[Category: Myeloid lymphoma leukemia protein]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Trithorax]]
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[[Category: Trithorax group protein]]
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Current revision

Crystal structure of Ash2L N-terminal domain

PDB ID 3s32

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