3szl

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[[Image:3szl.png|left|200px]]
 
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==IspH:Ligand Mutants - wt 70sec==
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The line below this paragraph, containing "STRUCTURE_3szl", creates the "Structure Box" on the page.
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<StructureSection load='3szl' size='340' side='right'caption='[[3szl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3szl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SZL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_3szl| PDB=3szl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3szl OCA], [https://pdbe.org/3szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3szl RCSB], [https://www.ebi.ac.uk/pdbsum/3szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3szl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
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===IspH:Ligand Mutants - wt 70sec===
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==See Also==
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*[[Iron–sulfur proteins|Iron–sulfur proteins]]
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*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
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*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22137895}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22137895 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22137895}}
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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==About this Structure==
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[[Category: Large Structures]]
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[[3szl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SZL OCA].
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[[Category: Bacher A]]
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[[Category: Eisenreich W]]
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==Reference==
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[[Category: Graewert T]]
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<ref group="xtra">PMID:022137895</ref><references group="xtra"/>
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[[Category: Groll M]]
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[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
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[[Category: Span I]]
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[[Category: Escherichia coli]]
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[[Category: Bacher, A.]]
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[[Category: Eisenreich, W.]]
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[[Category: Graewert, T.]]
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[[Category: Groll, M.]]
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[[Category: Span, I.]]
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[[Category: 4fe-4s iron-sulfur cluster]]
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[[Category: Conserved cysteine]]
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[[Category: Induced fit mechanism]]
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[[Category: Ipp and dmapp production final step]]
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[[Category: Non-mevalonate pathway]]
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[[Category: Oxidoreductase]]
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[[Category: Substrate hmbpp]]
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Current revision

IspH:Ligand Mutants - wt 70sec

PDB ID 3szl

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