3ui7

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[[Image:3ui7.png|left|200px]]
 
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==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia==
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The line below this paragraph, containing "STRUCTURE_3ui7", creates the "Structure Box" on the page.
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<StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ui7| PDB=3ui7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr>
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</table>
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===Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia===
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 22142545 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22142545}}
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==About this Structure==
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[[3ui7]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA].
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==See Also==
==See Also==
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*[[Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022142545</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Greenlee, W J.]]
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[[Category: Large Structures]]
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[[Category: Ho, G.]]
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[[Category: Greenlee WJ]]
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[[Category: Hodgson, R.]]
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[[Category: Ho G]]
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[[Category: Hruza, A.]]
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[[Category: Hodgson R]]
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[[Category: Mcelroy, W.]]
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[[Category: Hruza A]]
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[[Category: Smotryski, J.]]
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[[Category: Mcelroy W]]
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[[Category: Tulshian, D.]]
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[[Category: Smotryski J]]
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[[Category: Xiao, L.]]
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[[Category: Tulshian D]]
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[[Category: Yang, S.]]
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[[Category: Xiao L]]
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[[Category: Hydrolase]]
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[[Category: Yang S]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor complex]]
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[[Category: Mg binding]]
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[[Category: Zn binding]]
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Current revision

Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

PDB ID 3ui7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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