3qup

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[[Image:3qup.png|left|200px]]
 
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==Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)==
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The line below this paragraph, containing "STRUCTURE_3qup", creates the "Structure Box" on the page.
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<StructureSection load='3qup' size='340' side='right'caption='[[3qup]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LUN:(5-FLUORO-1H-INDOL-2-YL)[(3R)-1-[(3R)-PIPERIDIN-3-YL]SPIRO[INDOLE-3,3-PYRROLIDIN]-1(2H)-YL]METHANONE'>LUN</scene></td></tr>
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{{STRUCTURE_3qup| PDB=3qup | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qup OCA], [https://pdbe.org/3qup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qup RCSB], [https://www.ebi.ac.uk/pdbsum/3qup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qup ProSAT]</span></td></tr>
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</table>
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===Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)===
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== Function ==
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[https://www.uniprot.org/uniprot/TYRO3_MOUSE TYRO3_MOUSE] Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.<ref>PMID:15650770</ref> <ref>PMID:20363878</ref> <ref>PMID:21084607</ref> <ref>PMID:21291561</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22119469}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22119469 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22119469}}
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==About this Structure==
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[[3qup]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUP OCA].
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==Reference==
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<ref group="xtra">PMID:022119469</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Ohren JF]]
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[[Category: Ohren, J F.]]
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[[Category: Cytoplasmic surface]]
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[[Category: Gas6 ligand]]
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[[Category: Kinase domain]]
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[[Category: Phosphotransfer]]
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[[Category: Protein kinase inhibitor]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: Spirocycle]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

PDB ID 3qup

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