2lf6

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[[Image:2lf6.png|left|200px]]
 
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==Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A==
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The line below this paragraph, containing "STRUCTURE_2lf6", creates the "Structure Box" on the page.
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<StructureSection load='2lf6' size='340' side='right'caption='[[2lf6]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_savastanoi_pv._phaseolicola_1448A Pseudomonas savastanoi pv. phaseolicola 1448A]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LF6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf6 OCA], [https://pdbe.org/2lf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lf6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lf6 ProSAT]</span></td></tr>
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{{STRUCTURE_2lf6| PDB=2lf6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPAB1_PSE14 HPAB1_PSE14] Effector protein that plays different roles depending on the species and plant cultivars that interact with the pathogen. Acts as a virulence determinant by enhancing the development of disease symptoms and bacterial growth. Acts as an avirulence factor by eliciting hypersensitive response (HR) and plant resistance (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein.
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===Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A===
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Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors.,Singer AU, Wu B, Yee A, Houliston S, Xu X, Cui H, Skarina T, Garcia M, Semesi A, Arrowsmith CH, Savchenko A Biochemistry. 2012 Jan 10;51(1):1-3. Epub 2011 Dec 28. PMID:22191472<ref>PMID:22191472</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2lf6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22191472 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22191472}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lf6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._phaseolicola_1448a Pseudomonas syringae pv. phaseolicola 1448a]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF6 OCA].
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[[Category: Pseudomonas savastanoi pv. phaseolicola 1448A]]
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[[Category: Arrowsmith CH]]
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==Reference==
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[[Category: Garcia M]]
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<ref group="xtra">PMID:022191472</ref><references group="xtra"/>
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[[Category: Houliston S]]
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[[Category: Pseudomonas syringae pv. phaseolicola 1448a]]
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[[Category: Joachimiak A]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Montelione GT]]
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[[Category: Garcia, M.]]
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[[Category: Savchenko A]]
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[[Category: Houliston, S.]]
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[[Category: Semesi A]]
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[[Category: Joachimiak, A.]]
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[[Category: Singer AU]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Wu B]]
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[[Category: Montelione, G T.]]
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[[Category: Yee A]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: OCSP, Ontario Centre for Structural Proteomics.]]
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[[Category: Savchenko, A.]]
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[[Category: Semesi, A.]]
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[[Category: Singer, A U.]]
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[[Category: Wu, B.]]
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[[Category: Yee, A.]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Ocsp]]
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[[Category: Ontario centre for structural proteomic]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Type iii effector]]
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Current revision

Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A

PDB ID 2lf6

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