3vcd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3vcd is ON HOLD Authors: Sawaya, Michael R., King, Neil P., Sheffler, William, Baker, David, Yeates, Todd O. Description: Computationally Designed ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group R32== | |
| - | + | <StructureSection load='3vcd' size='340' side='right'caption='[[3vcd]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3vcd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. The September 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designed Protein Cages'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_9 10.2210/rcsb_pdb/mom_2013_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VCD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vcd OCA], [https://pdbe.org/3vcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vcd RCSB], [https://www.ebi.ac.uk/pdbsum/3vcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vcd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDUT_SALTY PDUT_SALTY] A minor shell protein of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation. The isolated BMC shell component protein ratio for J:A:B':B:K:T:U is approximately 15:10:7:6:1:1:2 (PubMed:12923081). Not required for structural integrity of BMCs nor to mitigate propionaldehyde toxicity, may selectively transport specific metabolites (PubMed:21239588). May be involved in electron transport across the BMC shell (Probable). Can be engineered to alter permeability of the BMC shell (PubMed:31674899).<ref>PMID:12923081</ref> <ref>PMID:21239588</ref> <ref>PMID:31674899</ref> <ref>PMID:20870711</ref> The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.<ref>PMID:28475631</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Designed Protein Cages]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
| + | [[Category: Salmonella enterica]] | ||
| + | [[Category: Baker D]] | ||
| + | [[Category: King NP]] | ||
| + | [[Category: Sawaya MR]] | ||
| + | [[Category: Sheffler W]] | ||
| + | [[Category: Yeates TO]] | ||
Current revision
Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group R32
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