2l9x

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[[Image:2l9x.png|left|200px]]
 
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==Trn- peptide of the two-component bacteriocin Thuricin CD==
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The line below this paragraph, containing "STRUCTURE_2l9x", creates the "Structure Box" on the page.
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<StructureSection load='2l9x' size='340' side='right'caption='[[2l9x]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_95/8201 Bacillus cereus 95/8201]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTH:D-THREONINE'>DTH</scene></td></tr>
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{{STRUCTURE_2l9x| PDB=2l9x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9x OCA], [https://pdbe.org/2l9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9x RCSB], [https://www.ebi.ac.uk/pdbsum/2l9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9x ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thuricin CD is an antimicrobial factor that consists of two peptides, Trn-alpha and Trn-beta, that exhibit synergistic activity against drug resistant strains of Clostridium difficile. Trn-alpha and Trn-beta each possess three sulfur to alpha-carbon thioether bridges for which the stereochemistry is unknown. This report presents the three-dimensional solution structures of Trn-alpha and Trn-beta. Structure calculations were performed for the eight possible stereoisomers of each peptide based on the same NMR data. The structure of the stereoisomer that best fit the experimental data was chosen as the representative structure for each peptide. It was determined that Trn-alpha has L-stereochemistry at Ser21 (alpha-R), L-stereochemistry at Thr25 (alpha-R), and D-stereochemistry at Thr28 (alpha-S) (an LLD isomer). Trn-beta was also found to be the LLD isomer, with L-stereochemistry at Thr21 (alpha-R), L-stereochemistry at Ala25 (alpha-R), and D-stereochemistry at Tyr28 (alpha-S).
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===Trn- peptide of the two-component bacteriocin Thuricin CD===
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The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to alpha-carbon cross-links.,Sit CS, McKay RT, Hill C, Ross RP, Vederas JC J Am Chem Soc. 2011 May 25;133(20):7680-3. Epub 2011 Apr 28. PMID:21526839<ref>PMID:21526839</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21526839}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2l9x" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21526839 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21526839}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacillus cereus 95/8201]]
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[[2l9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9X OCA].
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[[Category: Large Structures]]
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[[Category: Hill C]]
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==Reference==
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[[Category: Mckay RT]]
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<ref group="xtra">PMID:021526839</ref><references group="xtra"/>
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[[Category: Ross RP]]
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[[Category: Bacteria]]
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[[Category: Sit CS]]
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[[Category: Hill, C.]]
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[[Category: Vederas JC]]
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[[Category: Mckay, R T.]]
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[[Category: Ross, R P.]]
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[[Category: Sit, C S.]]
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[[Category: Vederas, J C.]]
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[[Category: Antimicrobial protein]]
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[[Category: Crosslinked]]
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[[Category: Helical loop]]
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[[Category: Post-translationally modified]]
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[[Category: Thioether bridge]]
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Current revision

Trn- peptide of the two-component bacteriocin Thuricin CD

PDB ID 2l9x

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