3tl8

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[[Image:3tl8.png|left|200px]]
 
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==The AvrPtoB-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III effector==
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The line below this paragraph, containing "STRUCTURE_3tl8", creates the "Structure Box" on the page.
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<StructureSection load='3tl8' size='340' side='right'caption='[[3tl8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tl8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TL8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_3tl8| PDB=3tl8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tl8 OCA], [https://pdbe.org/3tl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tl8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tl8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAK1_ARATH BAK1_ARATH] Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) via its interaction with FLS2 and the phosphorylation of BIK1. Involved in programmed cell death (PCD) control. Positively regulates the BR-dependent plant growth pathway and negatively regulates the BR-independent cell-death pathway.<ref>PMID:17600708</ref> <ref>PMID:17583510</ref> <ref>PMID:18694562</ref> <ref>PMID:18667726</ref> <ref>PMID:19124768</ref> <ref>PMID:20018402</ref> <ref>PMID:20404519</ref> <ref>PMID:21350342</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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To infect plants, Pseudomonas syringae pv. tomato delivers approximately 30 type III effector proteins into host cells, many of which interfere with PAMP-triggered immunity (PTI). One effector, AvrPtoB, suppresses PTI using a central domain to bind host BAK1, a kinase that acts with several pattern recognition receptors to activate defense signaling. A second AvrPtoB domain binds and suppresses the PTI-associated kinase Bti9 but is conversely recognized by the protein kinase Pto to activate effector-triggered immunity. We report the crystal structure of the AvrPtoB-BAK1 complex, which revealed structural similarity between these two AvrPtoB domains, suggesting that they arose by intragenic duplication. The BAK1 kinase domain is structurally similar to Pto, and a conserved region within both BAK1 and Pto interacts with AvrPtoB. BAK1 kinase activity is inhibited by AvrPtoB, and mutations at the interaction interface disrupt AvrPtoB virulence activity. These results shed light on a structural mechanism underlying host-pathogen coevolution.
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===The AvrPtoB-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III effector===
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Structural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III Effector.,Cheng W, Munkvold KR, Gao H, Mathieu J, Schwizer S, Wang S, Yan YB, Wang J, Martin GB, Chai J Cell Host Microbe. 2011 Dec 15;10(6):616-26. Epub 2011 Dec 8. PMID:22169508<ref>PMID:22169508</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tl8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Avirulence protein 3D structures|Avirulence protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22169508 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22169508}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3tl8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TL8 OCA].
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==Reference==
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<ref group="xtra">PMID:022169508</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
[[Category: Pseudomonas syringae pv. tomato]]
[[Category: Pseudomonas syringae pv. tomato]]
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[[Category: Chai, J.]]
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[[Category: Chai J]]
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[[Category: Cheng, W.]]
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[[Category: Cheng W]]
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[[Category: Gao, H.]]
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[[Category: Gao H]]
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[[Category: Bacterial pathogenesis]]
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[[Category: Pamp-triggered immunity]]
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[[Category: Plant immunity]]
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[[Category: Pseudomonas syringae]]
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[[Category: Solanum lycopersicum]]
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[[Category: Transferase-ligase complex]]
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Current revision

The AvrPtoB-BAK1 complex reveals two structurally similar kinaseinteracting domains in a single type III effector

PDB ID 3tl8

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