2lks

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[[Image:2lks.png|left|200px]]
 
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==Ff11-60==
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The line below this paragraph, containing "STRUCTURE_2lks", creates the "Structure Box" on the page.
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<StructureSection load='2lks' size='340' side='right'caption='[[2lks]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LKS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lks OCA], [https://pdbe.org/2lks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lks RCSB], [https://www.ebi.ac.uk/pdbsum/2lks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lks ProSAT]</span></td></tr>
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{{STRUCTURE_2lks| PDB=2lks | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have recently reported the atomic resolution structure of a low populated and transiently formed on-pathway folding intermediate of the FF domain from human HYPA/FBP11 [Korzhnev, D. M.; Religa, T. L.; Banachewicz, W.; Fersht, A. R.; Kay, L.E. Science2011, 329, 1312-1316]. The structure was determined on the basis of backbone chemical shift and bond vector orientation restraints of the invisible intermediate state measured using relaxation dispersion nuclear magnetic resonance (NMR) spectroscopy that were subsequently input into the database structure determination program, CS-Rosetta. As a cross-validation of the structure so produced, we present here the solution structure of a mimic of the folding intermediate that is highly populated in solution, obtained from the wild-type domain by mutagenesis that destabilizes the native state. The relaxation dispersion/CS-Rosetta structures of the intermediate are within 2 A of those of the mimic, with the nonnative interactions in the intermediate also observed in the mimic. This strongly confirms the structure of the FF domain folding intermediate, in particular, and validates the use of relaxation dispersion derived restraints in structural studies of invisible excited states, in general.
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===Ff11-60===
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Cross-Validation of the Structure of a Transiently Formed and Low Populated FF Domain Folding Intermediate Determined by Relaxation Dispersion NMR and CS-Rosetta.,Barette J, Velyvis A, Religa TL, Korzhnev DM, Kay LE J Phys Chem B. 2011 Dec 23. PMID:22148426<ref>PMID:22148426</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22148426}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lks" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22148426 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22148426}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lks]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LKS OCA].
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==Reference==
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<ref group="xtra">PMID:022148426</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barette, J.]]
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[[Category: Large Structures]]
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[[Category: Kay, L E.]]
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[[Category: Barette J]]
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[[Category: Korzhnev, D M.]]
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[[Category: Kay LE]]
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[[Category: Religa, T L.]]
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[[Category: Korzhnev DM]]
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[[Category: Velyvis, A.]]
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[[Category: Religa TL]]
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[[Category: Protein binding]]
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[[Category: Velyvis A]]

Current revision

Ff11-60

PDB ID 2lks

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