3pvn

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[[Image:3pvn.png|left|200px]]
 
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==Triclinic form of Human C-Reactive Protein in complex with Zinc==
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The line below this paragraph, containing "STRUCTURE_3pvn", creates the "Structure Box" on the page.
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<StructureSection load='3pvn' size='340' side='right'caption='[[3pvn]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pvn]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PVN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3pvn| PDB=3pvn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pvn OCA], [https://pdbe.org/3pvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pvn RCSB], [https://www.ebi.ac.uk/pdbsum/3pvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pvn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRP_HUMAN CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human C-reactive protein (CRP) is an acute phase protein, which harbours both host defence and scavenging properties. In this study, we obtained two new crystal forms of CRP, where CRP forms a symmetric, staggered dimer of pentamers. In one of these structures, obtained in the presence of HIV-1 Tat protein, this dimer of pentamers is stabilized by two zinc ions trapped within a cleft of the effector face of CRP. These two decameric interfaces involve complementary surfaces of CRP pentamers and bury a large area of ~2000 A(2) per pentamer, suggesting a biological role of this interface. These two novel decameric interfaces and the involvement of zinc might have important consequences in the understanding of CRP biological functions.
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===Triclinic form of Human C-Reactive Protein in complex with Zinc===
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A Staggered Decameric Assembly of Human C-Reactive Protein Stabilized by Zinc Ions Revealed by X-ray Crystallography.,Guillon C, Bigouagou UM, Folio C, Jeannin P, Delneste Y, Gouet P Protein Pept Lett. 2014;22(3):248-55. PMID:25552313<ref>PMID:25552313</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pvn" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3pvn]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PVN OCA].
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*[[C-reactive protein|C-reactive protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bigouagou, U Mavoungou.]]
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[[Category: Large Structures]]
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[[Category: Delneste, Y.]]
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[[Category: Delneste Y]]
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[[Category: Gouet, P.]]
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[[Category: Gouet P]]
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[[Category: Guillon, C.]]
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[[Category: Guillon C]]
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[[Category: Jeannin, P.]]
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[[Category: Jeannin P]]
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[[Category: Immune system]]
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[[Category: Mavoungou Bigouagou U]]
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[[Category: Pentraxin family]]
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Current revision

Triclinic form of Human C-Reactive Protein in complex with Zinc

PDB ID 3pvn

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