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Gramicidin
From Proteopedia
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| - | + | <StructureSection load='1gmk' size='350' side='right' caption='Gramicidin A complex with thiocyanate and K+ ion (purple) (PDB entry [[1gmk]])' scene='44/444642/Cv/2'> | |
| - | < | + | == Function == |
| + | [[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br /> | ||
| + | * '''GCDN S''' is an antibiotic cyclic polypeptide.<br /> | ||
| + | * '''GCDN D''' is a mixture of GCDN A, B, C. <br /> | ||
| + | See theoretical model of [[Gramicidin Channel in Lipid Bilayer]] and [[Gramicidin Channel in Lipid Bilayer (Spanish)]]. | ||
| + | ==Relevance == | ||
| + | GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>. | ||
| + | == Structural highlights: Gramicidin A== | ||
| - | + | Protein: | |
| - | + | ||
| - | + | <scene name='44/444642/Cv/7'>Chains</scene>, chain A in green, chain B in salmon. | |
| + | Non-standard residues: | ||
| + | <scene name='44/444642/Cv/8'>Ethanloamine</scene> | ||
| + | <scene name='44/444642/Cv/9'>D-leucine</scene> | ||
| + | <scene name='44/444642/Cv/10'>D-valine</scene> | ||
| + | <scene name='44/444642/Cv/11'>N-formyl-L-valine</scene> | ||
| - | + | Ligands: | |
| - | '' | + | <scene name='44/444642/Cv/4'>Methanol</scene>, C atom of methanol in cyan. |
| + | |||
| + | <scene name='44/444642/Cv/5'>Thiocyanate</scene>, C atom of thiocyanate in magenta. | ||
| + | |||
| + | <scene name='44/444642/Cv/6'>K+ ion</scene> (in purple). | ||
| + | </StructureSection> | ||
| + | == 3D Structures of Gramicidin == | ||
| - | == | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Gramicidin A | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | **[[1nt5]], [[1nt6]], [[1nrm]], [[1nru]], [[1ng8]], [[1kqe]], [[1jno]], [[1jo3]], [[1jo4]], [[1mic]], [[1mag]], [[1grm]] - GCDN A – NMR<br /> | |
| + | **[[1tkq]] - GCDN A + mini-GCDN A – NMR<br /> | ||
| + | **[[1av2]] - GCDN A + CsCl<br /> | ||
| + | **[[1gmk]] - GCDN A + KCNS | ||
| - | + | *Gramicidin D | |
| - | + | ||
| - | + | ||
| - | + | **[[2xdc]], [[1w5u]], [[1bdw]], [[1al4]], [[1alx]], [[1alz]], [[2y5m]], [[2y6n]] – GCDN D<br /> | |
| + | **[[3lml]], [[2izq]], [[4v6f]], [[3l8l]] - GCDN D + iodide<br /> | ||
| + | **[[1c4d]] - GCDN D + CsCl<br /> | ||
| + | **[[3zq8]] – GCDN D + monovaccenin | ||
| - | + | *Gramicidin S | |
| + | **[[1tk2]] – GCDN S + subtilisin savinase – ''Bacillus lentus'' | ||
| + | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Gramicidin
Updated on 16-January-2019
References
- ↑ Urry DW, Goodall MC, Glickson JD, Mayers DF. The gramicidin A transmembrane channel: characteristics of head-to-head dimerized (L,D) helices. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1907-11. PMID:5288776
- ↑ Kondejewski LH, Farmer SW, Wishart DS, Hancock RE, Hodges RS. Gramicidin S is active against both gram-positive and gram-negative bacteria. Int J Pept Protein Res. 1996 Jun;47(6):460-6. PMID:8836773
