2keo

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[[Image:2keo.png|left|200px]]
 
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==Solution NMR structure of human protein HS00059, cytochrome-b5-like domain of the HERC2 E3 ligase. Northeast structural genomics consortium (NESG) target ht98a==
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The line below this paragraph, containing "STRUCTURE_2keo", creates the "Structure Box" on the page.
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<StructureSection load='2keo' size='340' side='right'caption='[[2keo]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2keo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KEO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2keo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2keo OCA], [https://pdbe.org/2keo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2keo RCSB], [https://www.ebi.ac.uk/pdbsum/2keo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2keo ProSAT], [https://www.topsan.org/Proteins/NESGC/2keo TOPSAN]</span></td></tr>
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{{STRUCTURE_2keo| PDB=2keo | SCENE= }}
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</table>
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== Function ==
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===Solution NMR structure of human protein HS00059, cytochrome-b5-like domain of the HERC2 E3 ligase. Northeast structural genomics consortium (NESG) target ht98a===
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[https://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_21161328}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 21161328 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2keo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_21161328}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2keo ConSurf].
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[[2keo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KEO OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021161328</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Arrowsmith C]]
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[[Category: Fares, C.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Gutmanas, A.]]
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[[Category: Fares C]]
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[[Category: Lemak, A.]]
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[[Category: Gutmanas A]]
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[[Category: Li, Y.]]
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[[Category: Lemak A]]
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[[Category: Montelione, G.]]
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[[Category: Li Y]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione G]]
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[[Category: Quyang, H.]]
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[[Category: Quyang H]]
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[[Category: Herc2 cytochrome domain]]
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[[Category: Ligase]]
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[[Category: Metal-binding]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Phosphoprotein]]
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[[Category: Protein of unknown function]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Wd repeat]]
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[[Category: Zinc-finger]]
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Current revision

Solution NMR structure of human protein HS00059, cytochrome-b5-like domain of the HERC2 E3 ligase. Northeast structural genomics consortium (NESG) target ht98a

PDB ID 2keo

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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