3vne
From Proteopedia
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(New page: '''Unreleased structure''' The entry 3vne is ON HOLD Authors: Zhang, A.P.P. Description: TBA) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the ebolavirus protein VP24 from Sudan== | |
| + | <StructureSection load='3vne' size='340' side='right'caption='[[3vne]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3vne]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sudan_ebolavirus Sudan ebolavirus]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VNE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vne OCA], [https://pdbe.org/3vne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vne RCSB], [https://www.ebi.ac.uk/pdbsum/3vne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vne ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VP24_EBOSU VP24_EBOSU] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding. | ||
| - | + | ==See Also== | |
| - | + | *[[VP24|VP24]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Ebola Virus Proteins]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
| + | [[Category: Sudan ebolavirus]] | ||
| + | [[Category: Zhang APP]] | ||
Current revision
Structure of the ebolavirus protein VP24 from Sudan
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