4ae4

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(New page: '''Unreleased structure''' The entry 4ae4 is ON HOLD Authors: Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S.M., Allen, M.D., Bycroft, M., Perisic, O., Ye, Y., McDonald, B....)
Current revision (08:33, 9 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4ae4 is ON HOLD
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==The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain==
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<StructureSection load='4ae4' size='340' side='right'caption='[[4ae4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ae4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MSO:SELENOMETHIONINE+SELENOXIDE'>MSO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae4 OCA], [https://pdbe.org/4ae4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBAP1_HUMAN UBAP1_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The endosomal sorting complexes required for transport (ESCRTs) facilitate endosomal sorting of ubiquitinated cargo, MVB biogenesis, late stages of cytokinesis, and retroviral budding. Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37. The X-ray crystal structure of the C-terminal region of UBAP1 reveals a domain that we describe as a solenoid of overlapping UBAs (SOUBA). NMR analysis shows that each of the three rigidly arranged overlapping UBAs making up the SOUBA interact with ubiquitin. We demonstrate that UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins, such as tetherin (BST-2/CD317), by viral countermeasures, namely, the HIV-1 accessory protein Vpu and the Kaposi sarcoma-associated herpesvirus (KSHV) ubiquitin ligase K5.
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Authors: Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S.M., Allen, M.D., Bycroft, M., Perisic, O., Ye, Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S.J.D., Martin-Serrano, J., Williams, R.L.
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The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain.,Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL Structure. 2012 Mar 7;20(3):414-28. PMID:22405001<ref>PMID:22405001</ref>
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Description: The UBAP1 subunit of ESCRT-I interacts tightly with ubiquitin via a novel SOUBA domain
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ae4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Agromayor M]]
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[[Category: Allen MD]]
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[[Category: Bycroft M]]
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[[Category: Caballe A]]
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[[Category: Freund SM]]
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[[Category: Hofmann K]]
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[[Category: Kueck T]]
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[[Category: Martin-Serrano J]]
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[[Category: McDonald B]]
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[[Category: Neil SJD]]
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[[Category: Perisic O]]
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[[Category: Scheel H]]
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[[Category: Soler N]]
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[[Category: Williams RL]]
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[[Category: Ye Y]]

Current revision

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain

PDB ID 4ae4

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