2l97

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[[Image:2l97.jpg|left|200px]]
 
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==Solution structure of HtrA PDZ domain from Streptococcus pneumoniae==
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The line below this paragraph, containing "STRUCTURE_2l97", creates the "Structure Box" on the page.
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<StructureSection load='2l97' size='340' side='right'caption='[[2l97]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L97 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l97 OCA], [https://pdbe.org/2l97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l97 RCSB], [https://www.ebi.ac.uk/pdbsum/2l97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l97 ProSAT]</span></td></tr>
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{{STRUCTURE_2l97| PDB=2l97 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2US63_STRPN A0A0H2US63_STRPN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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High-temperature requirement A (HtrA), a highly conserved family of serine protease, plays crucial roles in protein quality control in prokaryotes and eukaryotes. The HtrA protein contains a C-terminal PDZ domain that mediates the proteolytic activity. Here we reported the solution structure of the HtrA PDZ domain from Streptococcus pneumoniae by NMR spectroscopy. Our results showed that the structure of HtrA PDZ domain, which contains three alpha-helices and five beta-strands, illustrates conservation within the canonical PDZ domains. In addition, we demonstrated the interactions between S. pneumoniae HtrA PDZ domain and peptides with the motif XXX-YYF-COOH by surface plasmon resonance. Besides, we identified the ligand binding surface and the critical residues responsible for ligand binding of HtrA PDZ domain by chemical shift perturbation and site-directed mutagenesis.
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===Solution structure of HtrA PDZ domain from Streptococcus pneumoniae===
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Solution structure of HtrA PDZ domain from Streptococcus pneumoniae and its interaction with YYF-COOH containing peptides.,Fan K, Zhang J, Zhang X, Tu X J Struct Biol. 2011 Oct;176(1):16-23. Epub 2011 Jul 2. PMID:21757011<ref>PMID:21757011</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l97" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21757011 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21757011}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2l97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L97 OCA].
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==Reference==
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<ref group="xtra">PMID:021757011</ref><ref group="xtra">PMID:020437142</ref><references group="xtra"/>
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[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Fan, K.]]
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[[Category: Fan K]]
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[[Category: Tu, X.]]
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[[Category: Tu X]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Htra-pdz]]
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[[Category: Protein binding]]
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Current revision

Solution structure of HtrA PDZ domain from Streptococcus pneumoniae

PDB ID 2l97

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OCA

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