3zu5

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[[Image:3zu5.jpg|left|200px]]
 
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==Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173==
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The line below this paragraph, containing "STRUCTURE_3zu5", creates the "Structure Box" on the page.
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<StructureSection load='3zu5' size='340' side='right'caption='[[3zu5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZU5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEW:1-(3-AMINO-2-METHYLBENZYL)-4-HEXYLPYRIDIN-2(1H)-ONE'>AEW</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene></td></tr>
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{{STRUCTURE_3zu5| PDB=3zu5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zu5 OCA], [https://pdbe.org/3zu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zu5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zu5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABV_YERPE FABV_YERPE] Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).<ref>PMID:22244758</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The recently discovered FabV enoyl-ACP reductase, which catalyzes the last step of the bacterial fatty acid biosynthesis (FAS-II) pathway, is a promising but unexploited drug target against the reemerging pathogen Yersinia pestis. The structure of Y. pestis FabV in complex with its cofactor reveals that the enzyme features the common architecture of the short-chain dehydrogenase reductase superfamily, but contains additional structural elements that are mostly folded around the usually flexible substrate-binding loop, thereby stabilizing it in a very tight conformation that seals the active site. The structures of FabV in complex with NADH and two newly developed 2-pyridone inhibitors provide insights for the development of new lead compounds, and suggest a mechanism by which the substrate-binding loop opens to admit the inhibitor, a motion that could also be coupled to the interaction of FabV with the acyl-carrier protein substrate.
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===Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173===
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Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.,Hirschbeck MW, Kuper J, Lu H, Liu N, Neckles C, Shah S, Wagner S, Sotriffer CA, Tonge PJ, Kisker C Structure. 2012 Jan 11;20(1):89-100. PMID:22244758<ref>PMID:22244758</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3zu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZU5 OCA].
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<div class="pdbe-citations 3zu5" style="background-color:#fffaf0;"></div>
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[[Category: Yersinia pestis]]
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== References ==
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[[Category: Hirschbeck, M W.]]
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<references/>
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[[Category: Kisker, C.]]
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__TOC__
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[[Category: Kuper, J.]]
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</StructureSection>
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[[Category: Tonge, P J.]]
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[[Category: Large Structures]]
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[[Category: Fatty acid biosynthesis ii]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Oxidoreductase]]
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[[Category: Hirschbeck MW]]
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[[Category: Short-chain dehydrogenase reductase superfamily]]
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[[Category: Kisker C]]
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[[Category: Structure-based drug design]]
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[[Category: Kuper J]]
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[[Category: Tonge PJ]]

Current revision

Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173

PDB ID 3zu5

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