4aco

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[[Image:4aco.png|left|200px]]
 
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==Structure of the budding yeast Ndc10 N-terminal domain==
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The line below this paragraph, containing "STRUCTURE_4aco", creates the "Structure Box" on the page.
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<StructureSection load='4aco' size='340' side='right'caption='[[4aco]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4aco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ACO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aco OCA], [https://pdbe.org/4aco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aco RCSB], [https://www.ebi.ac.uk/pdbsum/4aco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aco ProSAT]</span></td></tr>
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{{STRUCTURE_4aco| PDB=4aco | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBF3A_YEAST CBF3A_YEAST] Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have solved the X-ray structure of the amino-terminal half of the yeast kinetochore protein Ndc10 at 1.8 Angstrom resolution. This essential protein is a key constituent of the budding yeast centromere, and is essential for the recruitment of the centromeric nucleosome and establishment of the kinetochore. The fold of the protein shows unexpected similarities to the tyrosine recombinase/lambda-integrase family of proteins, most notably Cre, with some variation in the relative position of the sub-domains. This finding offers new insights into kinetochore evolution and the adaptation of a well-studied protein fold to a novel role. By comparison to tyrosine recombinases, and mutagenesis studies, we have been able to define some of the key DNA-binding motifs.
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===Structure of the budding yeast Ndc10 N-terminal domain===
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The structure of the yeast kinetochore Ndc10 DNA-binding domain reveals an unexpected evolutionary relationship to tyrosine recombinases.,Perriches T, Singleton MR J Biol Chem. 2012 Jan 3. PMID:22215672<ref>PMID:22215672</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4aco" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22215672}}, adds the Publication Abstract to the page
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22215672 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22215672}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4aco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACO OCA].
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==Reference==
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<ref group="xtra">PMID:022215672</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Perriches, T.]]
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[[Category: Perriches T]]
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[[Category: Singleton, M R.]]
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[[Category: Singleton MR]]
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[[Category: Dna binding protein]]
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Current revision

Structure of the budding yeast Ndc10 N-terminal domain

PDB ID 4aco

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