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2ztj

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[[Image:2ztj.png|left|200px]]
 
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==Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate==
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The line below this paragraph, containing "STRUCTURE_2ztj", creates the "Structure Box" on the page.
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<StructureSection load='2ztj' size='340' side='right'caption='[[2ztj]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ztj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
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{{STRUCTURE_2ztj| PDB=2ztj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ztj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztj OCA], [https://pdbe.org/2ztj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ztj RCSB], [https://www.ebi.ac.uk/pdbsum/2ztj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ztj ProSAT]</span></td></tr>
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</table>
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===Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate===
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== Function ==
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[https://www.uniprot.org/uniprot/HOSA_THET2 HOSA_THET2] Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate (PubMed:19996101, PubMed:12095615). Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway (PubMed:9868782). To a lesser extent, can also use oxaloacetate in place of 2-oxoglutarate, leading to citrate. Does not display 2-isopropylmalate synthase activity since it cannot use 2-oxoisovalerate (PubMed:12095615).<ref>PMID:12095615</ref> <ref>PMID:19996101</ref> <ref>PMID:9868782</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19996101}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19996101 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/2ztj_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19996101}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2ztj]] is a 1 chain structure of [[Homocitrate synthase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTJ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ztj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Homocitrate synthase]]
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*[[Homocitrate synthase|Homocitrate synthase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019996101</ref><references group="xtra"/>
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__TOC__
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[[Category: Homocitrate synthase]]
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</StructureSection>
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[[Category: Thermus thermophilus]]
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[[Category: Large Structures]]
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[[Category: Kuzuyama, T.]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Nishiyama, M.]]
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[[Category: Kuzuyama T]]
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[[Category: Okada, T.]]
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[[Category: Nishiyama M]]
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[[Category: Tomita, T.]]
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[[Category: Okada T]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Tomita T]]
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[[Category: Lysine biosynthesis]]
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[[Category: Substrate complex]]
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[[Category: Transferase]]
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Current revision

Crystal structure of homocitrate synthase from Thermus thermophilus complexed with alpha-ketoglutarate

PDB ID 2ztj

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