3zxe

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[[Image:3zxe.png|left|200px]]
 
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==Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor==
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The line below this paragraph, containing "STRUCTURE_3zxe", creates the "Structure Box" on the page.
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<StructureSection load='3zxe' size='340' side='right'caption='[[3zxe]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGZ:METHYL+2-O-[(S)-(BENZYLOXY)(HYDROXY)PHOSPHORYL]-3-DEOXY-3-{[(4-METHYLPHENYL)CARBONYL]AMINO}-1-THIO-BETA-D-GALACTOPYRANOSIDE'>PGZ</scene></td></tr>
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{{STRUCTURE_3zxe| PDB=3zxe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxe OCA], [https://pdbe.org/3zxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxe RCSB], [https://www.ebi.ac.uk/pdbsum/3zxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7) in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth. Producing ligands able to selectively target hGal-7 will offer promising tools for deciphering cancer processes in which hGal-7 is involved as well as present potential solutions for future therapeutics. Here we report the high resolution crystal structure of hGal-7 in complex with a synthetic 2-O-benzylphosphate-galactoside inhibitor (which is &gt;60-fold potent than its parent galactoside). The high resolution crystallographic analysis highlights the validity of using saccharide derivatives, conserving properties of the galactose binding, while enhanced affinity and specificity is provided by the added phosphate group. This structural information will allow the design of further inhibitor with improved potency and specificity. Structured digital abstract hGal-7 and hGal-7 bind by x-ray crystallography (View interaction).
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===Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor===
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Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor.,Masuyer G, Jabeen T, Oberg CT, Leffler H, Nilsson UJ, Acharya KR FEBS J. 2011 Nov 7. doi: 10.1111/j.1742-4658.2011.08414.x. PMID:22059385<ref>PMID:22059385</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zxe" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22059385}}, adds the Publication Abstract to the page
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*[[Galectin 3D structures|Galectin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22059385 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22059385}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3zxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXE OCA].
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==Reference==
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<ref group="xtra">PMID:022059385</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acharya, K R.]]
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[[Category: Large Structures]]
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[[Category: Leffler, H.]]
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[[Category: Acharya KR]]
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[[Category: Masuyer, G.]]
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[[Category: Leffler H]]
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[[Category: Nilsson, U J.]]
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[[Category: Masuyer G]]
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[[Category: Oberg, C T.]]
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[[Category: Nilsson UJ]]
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[[Category: Sugar binding protein]]
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[[Category: Oberg CT]]

Current revision

Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor

PDB ID 3zxe

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