2li8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:55, 1 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2li8.png|left|200px]]
 
-
<!--
+
==The solution structure of the Lin28-ZnF domains bound to AGGAGAU of pre-let-7 miRNA==
-
The line below this paragraph, containing "STRUCTURE_2li8", creates the "Structure Box" on the page.
+
<StructureSection load='2li8' size='340' side='right'caption='[[2li8]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2li8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LI8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2li8| PDB=2li8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2li8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2li8 OCA], [https://pdbe.org/2li8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2li8 RCSB], [https://www.ebi.ac.uk/pdbsum/2li8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2li8 ProSAT]</span></td></tr>
-
 
+
</table>
-
===The solution structure of the Lin28-ZnF domains bound to AGGAGAU of pre-let-7 miRNA===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/LN28A_HUMAN LN28A_HUMAN] Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.<ref>PMID:18951094</ref> <ref>PMID:19703396</ref>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22157959}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22157959 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22157959}}
+
-
 
+
-
==About this Structure==
+
-
[[2li8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LI8 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022157959</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Allain, F H.T.]]
+
[[Category: Large Structures]]
-
[[Category: Loughlin, F E.]]
+
[[Category: Allain FH-T]]
-
[[Category: Micro rna]]
+
[[Category: Loughlin FE]]
-
[[Category: Transcription-rna complex]]
+
-
[[Category: Zinc finger]]
+

Current revision

The solution structure of the Lin28-ZnF domains bound to AGGAGAU of pre-let-7 miRNA

PDB ID 2li8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2li8"
Personal tools