3tvx

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[[Image:3tvx.jpg|left|200px]]
 
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==The structure of PDE4A with pentoxifylline at 2.84A resolution==
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The line below this paragraph, containing "STRUCTURE_3tvx", creates the "Structure Box" on the page.
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<StructureSection load='3tvx' size='340' side='right'caption='[[3tvx]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TVX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PNX:3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>PNX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3tvx| PDB=3tvx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvx OCA], [https://pdbe.org/3tvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tvx RCSB], [https://www.ebi.ac.uk/pdbsum/3tvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4A_HUMAN PDE4A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:11566027</ref> <ref>PMID:17727341</ref>
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===The structure of PDE4A with pentoxifylline at 2.84A resolution===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22223051 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22223051}}
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==About this Structure==
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[[3tvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVX OCA].
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==Reference==
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<ref group="xtra">PMID:022223051</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Badger, J.]]
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[[Category: Large Structures]]
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[[Category: Sridhar, V.]]
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[[Category: Badger J]]
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[[Category: Hydrolase]]
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[[Category: Sridhar V]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

The structure of PDE4A with pentoxifylline at 2.84A resolution

PDB ID 3tvx

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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