2y5b

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[[Image:2y5b.jpg|left|200px]]
 
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==Structure of USP21 in complex with linear diubiquitin-aldehyde==
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<StructureSection load='2y5b' size='340' side='right'caption='[[2y5b]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2y5b| PDB=2y5b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5b OCA], [https://pdbe.org/2y5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5b RCSB], [https://www.ebi.ac.uk/pdbsum/2y5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBP21_HUMAN UBP21_HUMAN] Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.<ref>PMID:10799498</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Modification of proteins by ubiquitin (Ub) and Ub-like (Ubl) modifiers regulates a variety of cellular functions. The ability of Ub to form chains of eight structurally and functionally distinct types adds further complexity to the system. Ub-specific proteases (USPs) hydrolyse polyUb chains, and some have been suggested to be cross-reactive with Ubl modifiers, such as neural precursor cell expressed, developmentally downregulated 8 (NEDD8) and interferon-stimulated gene 15 (ISG15). Here, we report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15, but is inactive against NEDD8. A crystal structure of USP21 in complex with linear diUb aldehyde shows how USP21 interacts with polyUb through a previously unidentified second Ub- and ISG15-binding surface on the USP domain core. We also rationalize the inability of USP21 to target NEDD8 and identify differences that allow USPs to distinguish between structurally related modifications.
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===Structure of USP21 in complex with linear diubiquitin-aldehyde===
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Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.,Ye Y, Akutsu M, Reyes-Turcu F, Enchev RI, Wilkinson KD, Komander D EMBO Rep. 2011 Apr;12(4):350-7. Epub 2011 Mar 11. PMID:21399617<ref>PMID:21399617</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2y5b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21399617 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21399617}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2y5b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5B OCA].
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==Reference==
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<ref group="xtra">PMID:021399617</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Akutsu, M.]]
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[[Category: Large Structures]]
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[[Category: Enchev, R I.]]
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[[Category: Akutsu M]]
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[[Category: Komander, D.]]
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[[Category: Enchev RI]]
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[[Category: Reyes-Turcu, F.]]
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[[Category: Komander D]]
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[[Category: Wilkinson, K D.]]
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[[Category: Reyes-Turcu F]]
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[[Category: Ye, Y.]]
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[[Category: Wilkinson KD]]
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[[Category: Cell signaling]]
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[[Category: Ye Y]]
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[[Category: Isg15]]
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[[Category: Nedd8]]
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[[Category: Protein binding-hydrolase complex]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin specific protease]]
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[[Category: Usp]]
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Current revision

Structure of USP21 in complex with linear diubiquitin-aldehyde

PDB ID 2y5b

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