3qz2

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[[Image:3qz2.jpg|left|200px]]
 
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==The structure of cysteine-free human insulin degrading enzyme==
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The line below this paragraph, containing "STRUCTURE_3qz2", creates the "Structure Box" on the page.
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<StructureSection load='3qz2' size='340' side='right'caption='[[3qz2]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3qz2| PDB=3qz2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qz2 OCA], [https://pdbe.org/3qz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qz2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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===The structure of cysteine-free human insulin degrading enzyme===
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==See Also==
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3qz2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZ2 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Large Structures]]
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[[Category: Guo, Q.]]
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[[Category: Guo Q]]
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[[Category: Tang, W J.]]
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[[Category: Tang WJ]]
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[[Category: Hydrolase]]
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[[Category: Insulin degrading enzyme]]
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Current revision

The structure of cysteine-free human insulin degrading enzyme

PDB ID 3qz2

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OCA

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