Transferrin

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<StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
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== Function ==
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'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>. '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].
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'''Transferrin''' (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues. TF contains two lobes: at the N and C termini. Ovotransferrin (OTF) is a glycosylated TF of egg white albumen. For details see [[Molecular Playground/Transferrin]].
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===Transferrin===
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== Relevance ==
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Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>.
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[[1jnf]] – rTF - rabbit<br />
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== Structural highlights ==
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[[1suv]] – hTF + TF receptor]] - human<br />
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[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
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[[1h76]] – TF - pig
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===Transferrin N lobe===
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TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
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*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
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*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
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== 3D Structures of Transferrin ==
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[[Transferrin 3D structures]]
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[[1tfd]] – rTF N terminal<br />
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</StructureSection>
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[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
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[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
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[[1ryo]] - hTF N terminal + oxalate
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===Apo transferrin===
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== References ==
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<references/>
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[[1bp5]], [[1btj]] - hTF N terminal<br />
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[[Category:Topic Page]]
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[[2hau]], [[2hav]] – hTF (mutant)
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===Ovotransferrin===
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[[1ovt]], [[1n04]] – cOTF - chicken<br />
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[[2d3i]] – cOTF (Al)<br />
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[[1dot]] – dOTF - duck
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===Ovotransferrin N lobe===
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[[1ovb]], [[1gv8]] – dOTF NII domain <br />
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[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
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[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
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===Apo ovotransferrin===
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[[1aov]] – dOTF<br />
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[[1aiv]], [[1ryx]]– cOTF<br />
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[[1tfa]] - cOTF N terminal<br />
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[[1iq7]] - cOTF C terminal<br />
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[[1lfc]] – OTF residues 17-41 – bovine - NMR
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Current revision

Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code 3qyt).

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References

  1. ↑ de Jong G, van Dijk JP, van Eijk HG. The biology of transferrin. Clin Chim Acta. 1990 Sep;190(1-2):1-46. PMID:2208733
  2. ↑ Liu YS, Xu GY, Cheng DQ, Li YM. Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease. Hepatobiliary Pancreat Dis Int. 2005 May;4(2):265-8. PMID:15908327
  3. ↑ Yang N, Zhang H, Wang M, Hao Q, Sun H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19. PMID:23256035 doi:10.1038/srep00999

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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