3swz

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[[Image:3swz.png|left|200px]]
 
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==Human Cytochrome P450 17A1 in complex with TOK-001==
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The line below this paragraph, containing "STRUCTURE_3swz", creates the "Structure Box" on the page.
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<StructureSection load='3swz' size='340' side='right'caption='[[3swz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3swz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SWZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TOK:(3ALPHA,8ALPHA)-17-(1H-BENZIMIDAZOL-1-YL)ANDROSTA-5,16-DIEN-3-OL'>TOK</scene></td></tr>
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{{STRUCTURE_3swz| PDB=3swz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3swz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3swz OCA], [https://pdbe.org/3swz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3swz RCSB], [https://www.ebi.ac.uk/pdbsum/3swz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3swz ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>
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===Human Cytochrome P450 17A1 in complex with TOK-001===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22266943}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22266943 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22266943}}
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==About this Structure==
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[[3swz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SWZ OCA].
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==Reference==
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<ref group="xtra">PMID:022266943</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Steroid 17-alpha-monooxygenase]]
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[[Category: Large Structures]]
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[[Category: DeVore, N M.]]
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[[Category: DeVore NM]]
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[[Category: Scott, E E.]]
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[[Category: Scott EE]]
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[[Category: 17]]
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[[Category: 17a-hydroxylase]]
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[[Category: 20-lyase]]
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[[Category: Cyp17a1]]
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[[Category: Cytochrome p450]]
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[[Category: Cytochrome p450 oxidoreductase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Galeterone]]
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[[Category: Heme protein]]
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[[Category: Membrane]]
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[[Category: Microsome]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: P450]]
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[[Category: P450 17a1]]
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[[Category: P450c17]]
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[[Category: Tok-001]]
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[[Category: Vn/124-1]]
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Current revision

Human Cytochrome P450 17A1 in complex with TOK-001

PDB ID 3swz

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