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3iez

From Proteopedia

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[[Image:3iez.png|left|200px]]
 
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==Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2==
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The line below this paragraph, containing "STRUCTURE_3iez", creates the "Structure Box" on the page.
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<StructureSection load='3iez' size='340' side='right'caption='[[3iez]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IEZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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{{STRUCTURE_3iez| PDB=3iez | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iez OCA], [https://pdbe.org/3iez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iez RCSB], [https://www.ebi.ac.uk/pdbsum/3iez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iez ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2===
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== Function ==
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[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[3iez]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEZ OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3iez_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iez ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Crombet, L.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Crombet L]]
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[[Category: Nedyalkova, L.]]
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[[Category: Edwards AM]]
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[[Category: Park, H.]]
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[[Category: Nedyalkova L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Zhong, N.]]
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[[Category: Zhong N]]
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[[Category: Calmodulin-binding]]
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[[Category: Gap]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2

PDB ID 3iez

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