3uik

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[[Image:3uik.jpg|left|200px]]
 
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==crystal structure of human Survivin mutant K62Y/H80W in complex with H3(1-10) peptide==
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The line below this paragraph, containing "STRUCTURE_3uik", creates the "Structure Box" on the page.
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<StructureSection load='3uik' size='340' side='right'caption='[[3uik]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UIK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3uik| PDB=3uik | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uik OCA], [https://pdbe.org/3uik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uik RCSB], [https://www.ebi.ac.uk/pdbsum/3uik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uik ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref>
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===crystal structure of human Survivin mutant K62Y/H80W in complex with H3(1-10) peptide===
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==See Also==
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*[[Survivin|Survivin]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22244766}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22244766 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22244766}}
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==About this Structure==
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[[3uik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UIK OCA].
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==Reference==
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<ref group="xtra">PMID:022244766</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Du, J.]]
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[[Category: Large Structures]]
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[[Category: Patel, D J.]]
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[[Category: Du J]]
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[[Category: Apoptosis-apoptosis inhibitor complex]]
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[[Category: Patel DJ]]
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[[Category: Bir domain]]
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[[Category: Mitosis]]
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[[Category: Smac/diablo binding]]
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[[Category: T3 phosphorylated h3 binding]]
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Current revision

crystal structure of human Survivin mutant K62Y/H80W in complex with H3(1-10) peptide

PDB ID 3uik

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