3u78

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[[Image:3u78.png|left|200px]]
 
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==E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase==
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The line below this paragraph, containing "STRUCTURE_3u78", creates the "Structure Box" on the page.
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<StructureSection load='3u78' size='340' side='right'caption='[[3u78]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u78]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U78 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.689&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E67:7-[(5-AMINOPENTYL)OXY]-N~4~-(1-BENZYLPIPERIDIN-4-YL)-N~2~-[3-(DIMETHYLAMINO)PROPYL]-6-METHOXYQUINAZOLINE-2,4-DIAMINE'>E67</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3u78| PDB=3u78 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u78 OCA], [https://pdbe.org/3u78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u78 RCSB], [https://www.ebi.ac.uk/pdbsum/3u78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u78 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM7A_HUMAN KDM7A_HUMAN] Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.<ref>PMID:20023638</ref> <ref>PMID:20194436</ref> <ref>PMID:20622853</ref>
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===E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase===
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22227394 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22227394}}
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==About this Structure==
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[[3u78]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U78 OCA].
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==Reference==
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<ref group="xtra">PMID:022227394</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cheng, X.]]
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[[Category: Large Structures]]
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[[Category: Upadhyay, A K.]]
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[[Category: Cheng X]]
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[[Category: Bix analog]]
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[[Category: Upadhyay AK]]
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[[Category: Epigenetic]]
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[[Category: Histone lysine demethylation]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase

PDB ID 3u78

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