3uuo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:28, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3uuo.png|left|200px]]
 
-
<!--
+
==The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia==
-
The line below this paragraph, containing "STRUCTURE_3uuo", creates the "Structure Box" on the page.
+
<StructureSection load='3uuo' size='340' side='right'caption='[[3uuo]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3uuo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UUO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0CV:6-METHOXY-3,8-DIMETHYL-4-(PIPERAZIN-1-YL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>0CV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_3uuo| PDB=3uuo | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uuo OCA], [https://pdbe.org/3uuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uuo RCSB], [https://www.ebi.ac.uk/pdbsum/3uuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uuo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
-
===The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia===
+
==See Also==
-
 
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22222034}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22222034 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22222034}}
+
-
 
+
-
==About this Structure==
+
-
[[3uuo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUO OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022222034</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bercovici, A.]]
+
[[Category: Large Structures]]
-
[[Category: Bleickardt, C.]]
+
[[Category: Bercovici A]]
-
[[Category: Greenlee, W J.]]
+
[[Category: Bleickardt C]]
-
[[Category: Guzzi, M.]]
+
[[Category: Greenlee WJ]]
-
[[Category: Ho, G D.]]
+
[[Category: Guzzi M]]
-
[[Category: Hodgson, R.]]
+
[[Category: Ho GD]]
-
[[Category: Hruza, A.]]
+
[[Category: Hodgson R]]
-
[[Category: McElroy, W.]]
+
[[Category: Hruza A]]
-
[[Category: Mckittrick, B.]]
+
[[Category: McElroy W]]
-
[[Category: Mullins, D.]]
+
[[Category: Mckittrick B]]
-
[[Category: Nechuta, T.]]
+
[[Category: Mullins D]]
-
[[Category: Rindgen, D.]]
+
[[Category: Nechuta T]]
-
[[Category: Smith, E M.]]
+
[[Category: Rindgen D]]
-
[[Category: Smotryski, J.]]
+
[[Category: Smith EM]]
-
[[Category: Tan, Z.]]
+
[[Category: Smotryski J]]
-
[[Category: Tulshian, D.]]
+
[[Category: Tan Z]]
-
[[Category: Xiao, L.]]
+
[[Category: Tulshian D]]
-
[[Category: Yang, S.]]
+
[[Category: Xiao L]]
-
[[Category: Zhang, X.]]
+
[[Category: Yang S]]
-
[[Category: Hydrolase]]
+
[[Category: Zhang X]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Inhibitor complex]]
+
-
[[Category: Mg binding]]
+
-
[[Category: Zn binding]]
+

Current revision

The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia

PDB ID 3uuo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3uuo"
Personal tools