This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jb8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:41, 13 December 2023) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jb8.jpg|left|200px]]<br /><applet load="2jb8" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2jb8, resolution 1.53&Aring;" />
 
-
'''DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH 5-HYDROXY-4-KETO VALERIC ACID'''<br />
 
-
==About this Structure==
+
==Deacetoxycephalosporin C synthase complexed with 5-hydroxy-4-keto valeric acid==
-
2JB8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=HKV:'>HKV</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Deacetoxycephalosporin-C_synthase Deacetoxycephalosporin-C synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.20.1 1.14.20.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Fe+Binding+Site+For+Residue+A+1309'>AC1</scene> and <scene name='pdbsite=AC2:Hkv+Binding+Site+For+Residue+A+1310'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB8 OCA].
+
<StructureSection load='2jb8' size='340' side='right'caption='[[2jb8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-
[[Category: Deacetoxycephalosporin-C synthase]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2jb8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JB8 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HKV:4,5-DIOXOPENTANOIC+ACID'>HKV</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jb8 OCA], [https://pdbe.org/2jb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jb8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CEFE_STRCL CEFE_STRCL] Catalyzes the step from penicillin N to deacetoxy-cephalosporin C.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jb8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jb8 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Streptomyces clavuligerus]]
[[Category: Streptomyces clavuligerus]]
-
[[Category: Andersson, I.]]
+
[[Category: Andersson I]]
-
[[Category: Carbonera, C.]]
+
[[Category: Carbonera C]]
-
[[Category: Cicero, G.]]
+
[[Category: Cicero G]]
-
[[Category: Hajdu, J.]]
+
[[Category: Hajdu J]]
-
[[Category: Ranghino, G.]]
+
[[Category: Ranghino G]]
-
[[Category: Valegard, K.]]
+
[[Category: Valegard K]]
-
[[Category: FE]]
+
-
[[Category: HKV]]
+
-
[[Category: antibiotic biosynthesis]]
+
-
[[Category: deacetoxycephalosporin c synthase]]
+
-
[[Category: iron]]
+
-
[[Category: mononuclear ferrous enzyme]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: vitamin c]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 6 17:22:04 2008''
+

Current revision

Deacetoxycephalosporin C synthase complexed with 5-hydroxy-4-keto valeric acid

PDB ID 2jb8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jb8"
Personal tools