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| - | [[Image:3te3.png|left|200px]] | |
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| - | <!--
| + | ==Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1== |
| - | The line below this paragraph, containing "STRUCTURE_3te3", creates the "Structure Box" on the page.
| + | <StructureSection load='3te3' size='340' side='right'caption='[[3te3]], [[Resolution|resolution]] 2.69Å' scene=''> |
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet)
| + | == Structural highlights == |
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| + | <table><tr><td colspan='2'>[[3te3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TE3 FirstGlance]. <br> |
| - | or leave the SCENE parameter empty for the default display.
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.694Å</td></tr> |
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| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3te3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3te3 OCA], [https://pdbe.org/3te3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3te3 RCSB], [https://www.ebi.ac.uk/pdbsum/3te3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3te3 ProSAT]</span></td></tr> |
| - | {{STRUCTURE_3te3| PDB=3te3 | SCENE= }}
| + | </table> |
| - | | + | == Function == |
| - | ===Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1===
| + | [https://www.uniprot.org/uniprot/PK2L1_HUMAN PK2L1_HUMAN] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.<ref>PMID:10517637</ref> <ref>PMID:19812697</ref> <ref>PMID:23212381</ref> <ref>PMID:24336289</ref> |
| - | | + | == References == |
| - | | + | <references/> |
| - | <!-- | + | __TOC__ |
| - | The line below this paragraph, {{ABSTRACT_PUBMED_22193359}}, adds the Publication Abstract to the page
| + | </StructureSection> |
| - | (as it appears on PubMed at http://www.pubmed.gov), where 22193359 is the PubMed ID number.
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| - | -->
| + | |
| - | {{ABSTRACT_PUBMED_22193359}}
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| - | | + | |
| - | ==About this Structure== | + | |
| - | [[3te3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TE3 OCA]. | + | |
| - | | + | |
| - | ==Reference== | + | |
| - | <ref group="xtra">PMID:022193359</ref><references group="xtra"/> | + | |
| | [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| - | [[Category: Molland, K M]] | + | [[Category: Large Structures]] |
| - | [[Category: Yernool, D A.]] | + | [[Category: Molland KM]] |
| - | [[Category: C-terminal cytoplasmic regulatory domain]] | + | [[Category: Yernool DA]] |
| - | [[Category: Metal transport]]
| + | |
| - | [[Category: Oligomerization domain]]
| + | |
| - | [[Category: Trimeric coiled-coil]]
| + | |
| Structural highlights
Function
PK2L1_HUMAN Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.[1] [2] [3] [4]
References
- ↑ Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature. 1999 Sep 23;401(6751):383-6. PMID:10517637 doi:http://dx.doi.org/10.1038/43907
- ↑ Huque T, Cowart BJ, Dankulich-Nagrudny L, Pribitkin EA, Bayley DL, Spielman AI, Feldman RS, Mackler SA, Brand JG. Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One. 2009 Oct 8;4(10):e7347. doi: 10.1371/journal.pone.0007347. PMID:19812697 doi:http://dx.doi.org/10.1371/journal.pone.0007347
- ↑ Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun. 2012 Dec 4;3:1252. doi: 10.1038/ncomms2257. PMID:23212381 doi:http://dx.doi.org/10.1038/ncomms2257
- ↑ DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12;504(7479):315-8. doi: 10.1038/nature12832. PMID:24336289 doi:http://dx.doi.org/10.1038/nature12832
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