2pxh
From Proteopedia
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| - | [[Image:2pxh.jpg|left|200px]]<br /><applet load="2pxh" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2pxh, resolution 1.970Å" /> | ||
| - | '''Crystal structure of a bipyridylalanyl-tRNA synthetase'''<br /> | ||
| - | == | + | ==Crystal structure of a bipyridylalanyl-tRNA synthetase== |
| - | + | <StructureSection load='2pxh' size='340' side='right'caption='[[2pxh]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2pxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [https://pdbe.org/2pxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB], [https://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxh_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pxh ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
| - | + | [[Category: Liu W]] | |
| - | + | [[Category: Schultz PG]] | |
| - | [[Category: Liu | + | [[Category: Xie J]] |
| - | [[Category: Schultz | + | |
| - | [[Category: Xie | + | |
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Current revision
Crystal structure of a bipyridylalanyl-tRNA synthetase
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