4de4

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[[Image:4de4.jpg|left|200px]]
 
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==Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with HEPES==
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The line below this paragraph, containing "STRUCTURE_4de4", creates the "Structure Box" on the page.
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<StructureSection load='4de4' size='340' side='right'caption='[[4de4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4de4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r80 3r80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DE4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4de4 OCA], [https://pdbe.org/4de4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4de4 RCSB], [https://www.ebi.ac.uk/pdbsum/4de4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4de4 ProSAT]</span></td></tr>
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{{STRUCTURE_4de4| PDB=4de4 | SCENE= }}
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/O68183_ENTCA O68183_ENTCA]]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kinase-mediated resistance to antibiotics is a significant clinical challenge. These enzymes share a common protein fold characteristic of Ser/Thr/Tyr protein kinases. We screened 14 antibiotic resistance kinases against 80 chemically diverse protein kinase inhibitors to map resistance kinase chemical space. The screens identified molecules with both broad and narrow inhibition profiles, proving that protein kinase inhibitors offer privileged chemical matter with the potential to block antibiotic resistance. One example is the flavonol quercetin, which inhibited a number of resistance kinases in vitro and in vivo. This activity was rationalized by determination of the crystal structure of the aminoglycoside kinase APH(2'')-IVa in complex with quercetin and its antibiotic substrate kanamycin. Our data demonstrate that protein kinase inhibitors offer chemical scaffolds that can block antibiotic resistance, providing leads for co-drug design.
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===Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with HEPES===
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A small molecule discrimination map of the antibiotic resistance kinome.,Shakya T, Stogios PJ, Waglechner N, Evdokimova E, Ejim L, Blanchard JE, McArthur AG, Savchenko A, Wright GD Chem Biol. 2011 Dec 23;18(12):1591-601. PMID:22195561<ref>PMID:22195561</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4de4" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22195561}}, adds the Publication Abstract to the page
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*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22195561 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22195561}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4de4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_casseliflavus Enterococcus casseliflavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3r80 3r80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE4 OCA].
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==Reference==
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<ref group="xtra">PMID:022195561</ref><references group="xtra"/>
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[[Category: Enterococcus casseliflavus]]
[[Category: Enterococcus casseliflavus]]
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[[Category: Anderson, W F.]]
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[[Category: Large Structures]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Anderson WF]]
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[[Category: Egorova, O.]]
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[[Category: Di Leo R]]
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[[Category: Evdokimova, E.]]
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[[Category: Egorova O]]
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[[Category: Leo, R Di.]]
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[[Category: Evdokimova E]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Minasov, G.]]
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[[Category: Minasov G]]
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[[Category: Nocek, B.]]
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[[Category: Nocek B]]
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[[Category: Savchenko, A.]]
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[[Category: Savchenko A]]
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[[Category: Stogios, P J]]
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[[Category: Stogios PJ]]
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[[Category: Tan, K.]]
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[[Category: Tan K]]
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[[Category: Aminoglycoside phosphotransferase]]
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[[Category: Aminoglycoside]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: Eukaryotic protein kinase-like fold]]
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[[Category: Intracellular]]
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[[Category: Kinase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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Current revision

Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with HEPES

PDB ID 4de4

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