3ukm

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[[Image:3ukm.jpg|left|200px]]
 
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==Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)==
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The line below this paragraph, containing "STRUCTURE_3ukm", creates the "Structure Box" on the page.
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<StructureSection load='3ukm' size='340' side='right'caption='[[3ukm]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ukm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
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{{STRUCTURE_3ukm| PDB=3ukm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ukm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ukm OCA], [https://pdbe.org/3ukm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ukm RCSB], [https://www.ebi.ac.uk/pdbsum/3ukm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ukm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCNK1_HUMAN KCNK1_HUMAN] Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential.<ref>PMID:22282804</ref> <ref>PMID:8605869</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two-pore domain potassium (K(+)) channels (K2P channels) control the negative resting potential of eukaryotic cells and regulate cell excitability by conducting K(+) ions across the plasma membrane. Here, we present the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1 (TWIK-1). Unlike other K(+) channel structures, K2P1 is dimeric. An extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals. Openings within the transmembrane region expose the pore to the lipid bilayer and are filled with electron density attributable to alkyl chains. An interfacial helix appears structurally poised to affect gating. The structure lays a foundation to further investigate how K2P channels are regulated by diverse stimuli.
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===Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)===
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Crystal structure of the human two-pore domain potassium channel K2P1.,Miller AN, Long SB Science. 2012 Jan 27;335(6067):432-6. PMID:22282804<ref>PMID:22282804</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ukm" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22282804}}, adds the Publication Abstract to the page
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22282804 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22282804}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3ukm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKM OCA].
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==Reference==
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<ref group="xtra">PMID:022282804</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Long, S B.]]
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[[Category: Large Structures]]
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[[Category: Miller, A N.]]
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[[Category: Long SB]]
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[[Category: Eukaryotic]]
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[[Category: Miller AN]]
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[[Category: K2p channel]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Potassium channel]]
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[[Category: Two-pore domain potassium channel]]
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Current revision

Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)

PDB ID 3ukm

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