2lan

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[[Image:2lan.jpg|left|200px]]
 
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==NMR structure of Ca2+-bound CaBP1 N-domain with RDC==
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The line below this paragraph, containing "STRUCTURE_2lan", creates the "Structure Box" on the page.
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<StructureSection load='2lan' size='340' side='right'caption='[[2lan]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lan]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2lan| PDB=2lan | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lan OCA], [https://pdbe.org/2lan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lan RCSB], [https://www.ebi.ac.uk/pdbsum/2lan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lan ProSAT]</span></td></tr>
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</table>
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===NMR structure of Ca2+-bound CaBP1 N-domain with RDC===
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== Function ==
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[https://www.uniprot.org/uniprot/CABP1_HUMAN CABP1_HUMAN] Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity).<ref>PMID:11865310</ref> <ref>PMID:14570872</ref> <ref>PMID:15140941</ref> <ref>PMID:15980432</ref> <ref>PMID:15895247</ref>
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== References ==
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==About this Structure==
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<references/>
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[[2lan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAN OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ames, J.]]
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[[Category: Large Structures]]
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[[Category: Ca2+-bound closed form]]
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[[Category: Ames J]]
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[[Category: Ef-hand]]
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[[Category: Metal binding protein]]
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Current revision

NMR structure of Ca2+-bound CaBP1 N-domain with RDC

PDB ID 2lan

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