1wsu

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[[Image:1wsu.png|left|200px]]
 
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==C-terminal domain of elongation factor selB complexed with SECIS RNA==
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The line below this paragraph, containing "STRUCTURE_1wsu", creates the "Structure Box" on the page.
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<StructureSection load='1wsu' size='340' side='right'caption='[[1wsu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wsu]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsu OCA], [https://pdbe.org/1wsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsu RCSB], [https://www.ebi.ac.uk/pdbsum/1wsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsu ProSAT]</span></td></tr>
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{{STRUCTURE_1wsu| PDB=1wsu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SELB_MOOTH SELB_MOOTH] Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/1wsu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wsu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In bacteria, incorporation of selenocysteine, the 21(st) amino acid, into proteins requires elongation factor SelB, which has the unusual property of binding to both transfer RNA (tRNA) and mRNA. SelB binds to an mRNA hairpin formed by the selenocysteine insertion sequence (SECIS) with extremely high specificity, the molecular basis of which has been unknown. We have determined the crystal structure of the mRNA-binding domain of SelB in complex with SECIS RNA at a resolution of 2.3 A. This is the first example of a complex between an RNA and a winged-helix (WH) domain, a motif found in many DNA-binding proteins and recently discovered in RNA-binding proteins. Notably, RNA binding does not induce a major conformational change in the WH motif. The structure reveals a new mode of RNA recognition with a geometry that allows the complex to wrap around the small ribosomal subunit.
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===C-terminal domain of elongation factor selB complexed with SECIS RNA===
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Structural basis for mRNA recognition by elongation factor SelB.,Yoshizawa S, Rasubala L, Ose T, Kohda D, Fourmy D, Maenaka K Nat Struct Mol Biol. 2005 Feb;12(2):198-203. Epub 2005 Jan 23. PMID:15665870<ref>PMID:15665870</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1wsu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15665870 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15665870}}
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==About this Structure==
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[[1wsu]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Moorella_thermoacetica Moorella thermoacetica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSU OCA].
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==See Also==
==See Also==
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*[[SelB]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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*[[SelB|SelB]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:015665870</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Moorella thermoacetica]]
[[Category: Moorella thermoacetica]]
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[[Category: Fourmy, D.]]
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[[Category: Fourmy D]]
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[[Category: Kohda, D.]]
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[[Category: Kohda D]]
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[[Category: Maenaka, K.]]
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[[Category: Maenaka K]]
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[[Category: Ose, T.]]
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[[Category: Ose T]]
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[[Category: Rasubala, L.]]
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[[Category: Rasubala L]]
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[[Category: Yoshizawa, S.]]
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[[Category: Yoshizawa S]]
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[[Category: Translation-rna complex]]
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[[Category: Winged-helix]]
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Current revision

C-terminal domain of elongation factor selB complexed with SECIS RNA

PDB ID 1wsu

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