1nav

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[[Image:1nav.png|left|200px]]
 
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==Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1==
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The line below this paragraph, containing "STRUCTURE_1nav", creates the "Structure Box" on the page.
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<StructureSection load='1nav' size='340' side='right'caption='[[1nav]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NAV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IH5:{3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC+ACID'>IH5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1nav| PDB=1nav | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nav OCA], [https://pdbe.org/1nav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nav RCSB], [https://www.ebi.ac.uk/pdbsum/1nav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nav ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/na/1nav_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nav ConSurf].
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<div style="clear:both"></div>
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===Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1===
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==See Also==
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*[[Thyroid hormone receptor 3D structures|Thyroid hormone receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12699376 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_12699376}}
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==About this Structure==
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[[1nav]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAV OCA].
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==Reference==
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<ref group="xtra">PMID:012699376</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bladh, L G.]]
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[[Category: Large Structures]]
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[[Category: Collazo, A M.Garcia.]]
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[[Category: Bladh LG]]
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[[Category: Garg, N.]]
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[[Category: Garcia Collazo AM]]
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[[Category: George, R.]]
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[[Category: Garg N]]
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[[Category: Grover, G.]]
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[[Category: George R]]
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[[Category: Husman, B.]]
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[[Category: Grover G]]
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[[Category: Koehler, K.]]
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[[Category: Husman B]]
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[[Category: Li, Y L.]]
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[[Category: Koehler K]]
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[[Category: Litten, C.]]
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[[Category: Li YL]]
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[[Category: Ljunggren, J.]]
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[[Category: Litten C]]
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[[Category: Malm, J.]]
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[[Category: Ljunggren J]]
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[[Category: Mellin, C.]]
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[[Category: Malm J]]
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[[Category: Mellstrom, K.]]
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[[Category: Mellin C]]
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[[Category: Persson, K.]]
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[[Category: Mellstrom K]]
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[[Category: Sleph, P G.]]
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[[Category: Persson K]]
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[[Category: Ye, L.]]
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[[Category: Sleph PG]]
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[[Category: Complex]]
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[[Category: Ye L]]
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[[Category: Ligand]]
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[[Category: Membrane protein]]
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[[Category: Nuclear receptor]]
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[[Category: Thyroid receptor]]
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Current revision

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

PDB ID 1nav

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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