2rcz

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[[Image:2rcz.jpg|left|200px]]<br /><applet load="2rcz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2rcz, resolution 1.700&Aring;" />
 
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'''Structure of the second PDZ domain of ZO-1'''<br />
 
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==Overview==
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==Structure of the second PDZ domain of ZO-1==
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ZO-1 is a multidomain protein involved in cell-cell junctions and contains, three PDZ domains, which are necessary for its function in vivo. PDZ, domains play a central role in assembling diverse protein complexes, through their ability to recognize short peptide motifs on other proteins., We determined the structure of the second of the three PDZ domains of, ZO-1, which is known to promote dimerization as well as bind to C-terminal, sequences on connexins. The dimer is stabilized by extensive symmetrical, domain swapping of beta-strands, which is unlike any other known mechanism, of PDZ dimerization. The canonical peptide-binding groove remains intact, in both subunits of the PDZ2 dimer and is created by elements contributed, from both monomers. This unique structure reveals an additional example of, how PDZ domains dimerize and has multiple implications for both peptide, binding and oligomerization in vivo.
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<StructureSection load='2rcz' size='340' side='right'caption='[[2rcz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2rcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCZ FirstGlance]. <br>
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2RCZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCZ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcz OCA], [https://pdbe.org/2rcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcz RCSB], [https://www.ebi.ac.uk/pdbsum/2rcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcz ProSAT]</span></td></tr>
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==Reference==
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</table>
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Domain swapping within PDZ2 is responsible for dimerization of ZO proteins., Fanning AS, Lye MF, Anderson JM, Lavie A, J Biol Chem. 2007 Dec 28;282(52):37710-6. Epub 2007 Oct 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17928286 17928286]
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== Function ==
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[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lavie, A.]]
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[[Category: Lavie A]]
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[[Category: Lye, M.F.]]
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[[Category: Lye MF]]
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[[Category: cell junction]]
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[[Category: domain-swapping]]
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[[Category: membrane]]
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[[Category: pdz]]
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[[Category: phosphorylation]]
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[[Category: protein binding]]
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[[Category: sh3 domain]]
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[[Category: tight junction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:13:26 2008''
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Current revision

Structure of the second PDZ domain of ZO-1

PDB ID 2rcz

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