3tgm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:27, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3tgm.png|left|200px]]
 
-
<!--
+
==X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(1H-imidazol-1-yl)-4,4-diphenyl-2 butanone==
-
The line below this paragraph, containing "STRUCTURE_3tgm", creates the "Structure Box" on the page.
+
<StructureSection load='3tgm' size='340' side='right'caption='[[3tgm]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3tgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGM FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TG:1-(1H-IMIDAZOL-1-YL)-4,4-DIPHENYLBUTAN-2-ONE'>3TG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
-
{{STRUCTURE_3tgm| PDB=3tgm | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgm OCA], [https://pdbe.org/3tgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgm RCSB], [https://www.ebi.ac.uk/pdbsum/3tgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgm ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/HMOX1_HUMAN HMOX1_HUMAN] Defects in HMOX1 are the cause of heme oxygenase 1 deficiency (HMOX1D) [MIM:[https://omim.org/entry/614034 614034]. A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.<ref>PMID:9884342</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HMOX1_HUMAN HMOX1_HUMAN] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
-
===X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(1H-imidazol-1-yl)-4,4-diphenyl-2 butanone===
+
==See Also==
-
 
+
*[[Heme oxygenase 3D structures|Heme oxygenase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_22276118}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 22276118 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_22276118}}
+
-
 
+
-
==About this Structure==
+
-
[[3tgm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGM OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022276118</ref><references group="xtra"/>
+
-
[[Category: Heme oxygenase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Jia, Z.]]
+
[[Category: Large Structures]]
-
[[Category: Rahman, M N.]]
+
[[Category: Jia Z]]
-
[[Category: Alpha helix]]
+
[[Category: Rahman MN]]
-
[[Category: Heme]]
+
-
[[Category: Microsome]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+

Current revision

X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(1H-imidazol-1-yl)-4,4-diphenyl-2 butanone

PDB ID 3tgm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tgm"
Personal tools