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4doh
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4doh is ON HOLD Authors: Logsdon, N.J., Walter, M.R. Description: IL20/IL201/IL20R2 Ternary Complex) |
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| - | '''Unreleased structure''' | ||
| - | + | ==IL20/IL201/IL20R2 Ternary Complex== | |
| + | <StructureSection load='4doh' size='340' side='right'caption='[[4doh]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4doh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DOH FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4doh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4doh OCA], [https://pdbe.org/4doh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4doh RCSB], [https://www.ebi.ac.uk/pdbsum/4doh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4doh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IL20_HUMAN IL20_HUMAN]] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines IL-19 and IL-24, designated IL-20 subfamily cytokines (IL-20SFCs), induce cellular responses through an IL-20R1/IL-20R2 (type I) receptor heterodimer, whereas IL-20 and IL-24 also signal through the IL-22R1/IL-20R2 (type II) receptor complex. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands. The structure also defines how the receptor-cytokine interfaces are affinity tuned to allow distinct signaling through a receptor complex shared by three different ligands. Our results provide unique insights into the complexity of IL-20SFC signaling that may be critical in the design of mechanistic-based inhibitors of IL-20SFC-mediated inflammatory disease. | ||
| - | + | Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.,Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. Epub 2012 Jul 16. PMID:22802649<ref>PMID:22802649</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4doh" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Logsdon NJ]] | ||
| + | [[Category: Walter MR]] | ||
Current revision
IL20/IL201/IL20R2 Ternary Complex
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