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3uj0

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[[Image:3uj0.jpg|left|200px]]
 
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==Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.==
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The line below this paragraph, containing "STRUCTURE_3uj0", creates the "Structure Box" on the page.
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<StructureSection load='3uj0' size='340' side='right'caption='[[3uj0]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJ0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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{{STRUCTURE_3uj0| PDB=3uj0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uj0 OCA], [https://pdbe.org/3uj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3uj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uj0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
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===Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.===
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==See Also==
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*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22286060}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22286060 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22286060}}
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==About this Structure==
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[[3uj0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ0 OCA].
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==Reference==
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<ref group="xtra">PMID:022286060</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ikura, M.]]
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[[Category: Ikura M]]
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[[Category: Ishiyama, N.]]
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[[Category: Ishiyama N]]
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[[Category: Seo, M D.]]
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[[Category: Seo MD]]
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[[Category: Stathopulos, P.]]
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[[Category: Stathopulos P]]
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[[Category: 5-trisphosphate]]
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[[Category: Inositol 1]]
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[[Category: Ip3-binding core domain]]
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[[Category: Ip3-bound form]]
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[[Category: Signaling protein]]
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[[Category: Suppressor domain]]
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Current revision

Crystal structure of the inositol 1,4,5-trisphosphate receptor with ligand bound form.

PDB ID 3uj0

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