3td6

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[[Image:3td6.jpg|left|200px]]
 
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==Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis from trigonal partially dehydrated crystal==
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The line below this paragraph, containing "STRUCTURE_3td6", creates the "Structure Box" on the page.
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<StructureSection load='3td6' size='340' side='right'caption='[[3td6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3td6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TD6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3td6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3td6 OCA], [https://pdbe.org/3td6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3td6 RCSB], [https://www.ebi.ac.uk/pdbsum/3td6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3td6 ProSAT]</span></td></tr>
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{{STRUCTURE_3td6| PDB=3td6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray structures of new crystal forms of peptidyl-tRNA hydrolase from M. tuberculosis reported here and the results of previous X-ray studies of the enzyme from different sources provide a picture of the functionally relevant plasticity of the protein molecule. The new X-ray results confirm the connection deduced previously between the closure of the lid at the peptide-binding site and the opening of the gate that separates the peptide-binding and tRNA-binding sites. The plasticity of the molecule indicated by X-ray structures is in general agreement with that deduced from the available solution NMR results. The correlation between the lid and the gate movements is not, however, observed in the NMR structure.
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===Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis from trigonal partially dehydrated crystal===
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Structures of new crystal forms of Mycobacterium tuberculosis peptidyl-tRNA hydrolase and functionally important plasticity of the molecule.,Selvaraj M, Ahmad R, Varshney U, Vijayan M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt, 2):124-8. Epub 2012 Jan 21. PMID:22297982<ref>PMID:22297982</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3td6" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22297982}}, adds the Publication Abstract to the page
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*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22297982 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22297982}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3td6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD6 OCA].
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Ahmad R]]
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==Reference==
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[[Category: Selvaraj M]]
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<ref group="xtra">PMID:022297982</ref><references group="xtra"/>
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[[Category: Varshney U]]
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[[Category: Aminoacyl-tRNA hydrolase]]
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[[Category: Vijayan M]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Ahmad, R.]]
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[[Category: Selvaraj, M.]]
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[[Category: Varshney, U.]]
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[[Category: Vijayan, M.]]
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[[Category: Cytosol]]
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[[Category: Hydrolase]]
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[[Category: Hydrolysis of peptidyl-trna]]
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[[Category: Peptidyl-trna]]
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[[Category: Pth]]
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Current revision

Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis from trigonal partially dehydrated crystal

PDB ID 3td6

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