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Sm-like protein

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{{STRUCTURE_2y9a| PDB=2y9a | SIZE=400| SCENE= |right|CAPTION=Human U4 snRNP core domain [[2y9a]] }}
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<StructureSection load='1m8v' size='350' side='right' scene='' caption='Sm1 7-member ring dimer complex with RNA, UMP and Ca+2 (green) ions [[1m8v]]'>
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'''Sm-like proteins''' are ring-shaped oligomers of 6-7 members which show nucleic acid-binding activity<ref>PMID:15009882</ref>. In eukaryotes 7 sm-like proteins (LSm2p-LSm8p) are associated with U6 snRNA<ref>PMID:10747033</ref>. For details on Sm1 of ''Archaeoglobus fulgidus'' see [[AF-Sm1]]. For details on the human protein see [[Lsm]].
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'''Sm-like proteins''' are ring-shaped oligomers of 6-7 members which show nucleic acid-binding activity. The '''Sm proteins''' together with snRNA molecules form the core of the snRNP
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== 3D Structures of Sm-like protein ==
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[[Sm-like protein 3D structures]]
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{{TOC limit|limit=2}}
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== 3D Structures of Sm protein ==
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[[1n9r]], [[1n9s]] – ySmF – yeast<br />
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[[3pgw]] – hSmB + hSmD1 + hSmD3 + hSmE + hSmF + hSmG + hU1 snRNP + DNA – human<br />
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[[2y9a]], [[2y9b]], [[2y9c]], [[2y9d]] - hSmB + hSmD1 + hSmD2 + hSmD3 + hSmE + hSmF + hSmG + hU4A snRNP <br />
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[[3s6n]] - hSmD1 + hSmD2 + hSmD3 + hSmE + hSmF + hSmG + SMN-interacting protein + SMN protein
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===Sm-like protein===
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[[1i81]], [[1jri]], [[1mgq]], [[1jbm]] – MtSm – ''Methanothermobacter thermautotrophicus''<br />
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[[1loj]] – MtSm + UMP<br />
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[[1i8f]], [[1m5q]], [[1lnx]] – Sm – ''Pyrobaculum aerophilum''<br />
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[[1i4k]] – AfSm1 – ''Archaeoglobus fulgidus''<br />
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[[1i5l]] – AfSm1 + RNA<br />
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[[1ljo]] – AfSm2<br />
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[[1m8v]] – PaSm1 + RNA – ''Pyrococcus abyssii''<br />
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[[1h64]] – PaSm<br />
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[[2fb7]] – Sm – zebra fish – NMR<br />
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[[3bw1]] – ySmX4
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[[3pgg]] – LSm5 – ''Cryptosporidium parvum''<br />
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[[3swn]] – LSm5 + LSm6 + LSm7 – fission yeast
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== References ==
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<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Sm1 7-member ring dimer complex with RNA, UMP and Ca+2 (green) ions 1m8v

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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