3v79

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[[Image:3v79.png|left|200px]]
 
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==Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence==
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The line below this paragraph, containing "STRUCTURE_3v79", creates the "Structure Box" on the page.
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<StructureSection load='3v79' size='340' side='right'caption='[[3v79]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3v79]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V79 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v79 OCA], [https://pdbe.org/3v79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v79 RCSB], [https://www.ebi.ac.uk/pdbsum/3v79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v79 ProSAT]</span></td></tr>
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{{STRUCTURE_3v79| PDB=3v79 | SCENE= }}
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</table>
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== Function ==
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===Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence===
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[https://www.uniprot.org/uniprot/MAML1_HUMAN MAML1_HUMAN] Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.<ref>PMID:11101851</ref> <ref>PMID:11390662</ref> <ref>PMID:12050117</ref> <ref>PMID:15546612</ref> <ref>PMID:17317671</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3v79]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V79 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blacklow, S.]]
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[[Category: Large Structures]]
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[[Category: Nam, Y.]]
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[[Category: Blacklow S]]
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[[Category: Sliz, P.]]
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[[Category: Nam Y]]
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[[Category: Ankyrin]]
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[[Category: Sliz P]]
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[[Category: Beta-trefoil]]
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[[Category: Dna binding]]
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[[Category: Transcription activation]]
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[[Category: Transcription-dna complex]]
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Current revision

Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence

PDB ID 3v79

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