2l9r

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[[Image:2l9r.png|left|200px]]
 
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==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A==
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The line below this paragraph, containing "STRUCTURE_2l9r", creates the "Structure Box" on the page.
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<StructureSection load='2l9r' size='340' side='right'caption='[[2l9r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9r OCA], [https://pdbe.org/2l9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9r RCSB], [https://www.ebi.ac.uk/pdbsum/2l9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9r ProSAT]</span></td></tr>
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{{STRUCTURE_2l9r| PDB=2l9r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKX31_HUMAN NKX31_HUMAN] Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.<ref>PMID:19462257</ref>
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===Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A===
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==See Also==
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*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
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== References ==
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==About this Structure==
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<references/>
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[[2l9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9R OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton TB]]
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[[Category: Everett, J K.]]
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[[Category: Ciccosanti C]]
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[[Category: Hamilton, K.]]
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[[Category: Everett JK]]
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[[Category: Huang, Y J.]]
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[[Category: Hamilton K]]
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[[Category: Lee, H W.]]
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[[Category: Huang YJ]]
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[[Category: Liu, G.]]
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[[Category: Lee H-W]]
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[[Category: Montelione, G T.]]
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[[Category: Liu G]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Wang, H B.]]
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[[Category: Wang HB]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Methods development]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A

PDB ID 2l9r

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