3ru8

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[[Image:3ru8.png|left|200px]]
 
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==Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab==
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The line below this paragraph, containing "STRUCTURE_3ru8", creates the "Structure Box" on the page.
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<StructureSection load='3ru8' size='340' side='right'caption='[[3ru8]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ru8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus], [https://en.wikipedia.org/wiki/Thermobifida_fusca Thermobifida fusca] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RU8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3ru8| PDB=3ru8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ru8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ru8 OCA], [https://pdbe.org/3ru8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ru8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ru8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ru8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[https://omim.org/entry/614102 614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The manipulation of protein backbone structure to control interaction and function is a challenge for protein engineering. We integrated computational design with experimental selection for grafting the backbone and side chains of a two-segment HIV gp120 epitope, targeted by the cross-neutralizing antibody b12, onto an unrelated scaffold protein. The final scaffolds bound b12 with high specificity and with affinity similar to that of gp120, and crystallographic analysis of a scaffold bound to b12 revealed high structural mimicry of the gp120-b12 complex structure. The method can be generalized to design other functional proteins through backbone grafting.
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===Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab===
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Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.,Azoitei ML, Correia BE, Ban YE, Carrico C, Kalyuzhniy O, Chen L, Schroeter A, Huang PS, McLellan JS, Kwong PD, Baker D, Strong RK, Schief WR Science. 2011 Oct 21;334(6054):373-6. PMID:22021856<ref>PMID:22021856</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ru8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22021856}}, adds the Publication Abstract to the page
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*[[Antibody 3D structures|Antibody 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22021856 is the PubMed ID number.
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*[[3D structures of human antibody|3D structures of human antibody]]
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== References ==
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{{ABSTRACT_PUBMED_22021856}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ru8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus,_synthetic_construct,_thermomonospora_fusca Human immunodeficiency virus, synthetic construct, thermomonospora fusca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RU8 OCA].
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==Reference==
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<ref group="xtra">PMID:022021856</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Human immunodeficiency virus, synthetic construct, thermomonospora fusca]]
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[[Category: Human immunodeficiency virus]]
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[[Category: Carrico, C T.D.]]
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[[Category: Large Structures]]
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[[Category: Strong, R K.]]
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[[Category: Synthetic construct]]
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[[Category: Binding epitope from hiv on a heterologous protein]]
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[[Category: Thermobifida fusca]]
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[[Category: De novo protein]]
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[[Category: Carrico CTD]]
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[[Category: Immune system]]
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[[Category: Strong RK]]

Current revision

Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab

PDB ID 3ru8

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