3nzl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nzl" [edit=sysop:move=sysop])
Current revision (09:29, 30 October 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3nzl.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B==
-
The line below this paragraph, containing "STRUCTURE_3nzl", creates the "Structure Box" on the page.
+
<StructureSection load='3nzl' size='340' side='right'caption='[[3nzl]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3nzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NZL FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.199&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_3nzl| PDB=3nzl | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nzl OCA], [https://pdbe.org/3nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nzl RCSB], [https://www.ebi.ac.uk/pdbsum/3nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nzl ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/SATB1_HUMAN SATB1_HUMAN] Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.<ref>PMID:1505028</ref> <ref>PMID:9111059</ref> <ref>PMID:9548713</ref> <ref>PMID:10595394</ref> <ref>PMID:11463840</ref> <ref>PMID:12374985</ref> <ref>PMID:12692553</ref> <ref>PMID:15618465</ref> <ref>PMID:15713622</ref> <ref>PMID:16377216</ref> <ref>PMID:16630892</ref> <ref>PMID:17376900</ref> <ref>PMID:17173041</ref> <ref>PMID:18337816</ref> <ref>PMID:19332023</ref> <ref>PMID:19430959</ref> <ref>PMID:19103759</ref> <ref>PMID:19247486</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[3nzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NZL OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/3nzl_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nzl ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Abashidze, M.]]
+
[[Category: Large Structures]]
-
[[Category: Acton, T B.]]
+
[[Category: Abashidze M]]
-
[[Category: Ciccosanti, C.]]
+
[[Category: Acton TB]]
-
[[Category: Everett, J K.]]
+
[[Category: Ciccosanti C]]
-
[[Category: Forouhar, F.]]
+
[[Category: Everett JK]]
-
[[Category: Hunt, J F.]]
+
[[Category: Forouhar F]]
-
[[Category: Kuzin, A P.]]
+
[[Category: Hunt JF]]
-
[[Category: Montelione, G T.]]
+
[[Category: Kuzin AP]]
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
[[Category: Montelione GT]]
-
[[Category: Nair, R.]]
+
[[Category: Nair R]]
-
[[Category: Patel, P.]]
+
[[Category: Patel P]]
-
[[Category: Rost, B.]]
+
[[Category: Rost B]]
-
[[Category: Seetharaman, J.]]
+
[[Category: Seetharaman J]]
-
[[Category: Shastry, R.]]
+
[[Category: Shastry R]]
-
[[Category: Tong, L.]]
+
[[Category: Tong L]]
-
[[Category: Xiao, R.]]
+
[[Category: Xiao R]]
-
[[Category: Alpha-helical domain]]
+
-
[[Category: Nesg]]
+
-
[[Category: Northeast structural genomics consortium]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi-biology]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B

PDB ID 3nzl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nzl"
Personal tools